Overview
Semaglutide is a synthetic GLP-1 receptor agonist (GLP-1 RA) and fatty acid-modified analogue of human glucagon-like peptide-1 (GLP-1) with approximately 94% sequence homology to native GLP-1(7-37). Its C18 fatty diacid modification enables reversible albumin binding, extending the half-life to approximately 7 days. Semaglutide has become one of the most extensively studied metabolic peptides globally, with published research spanning pancreatic beta-cell function, cardiovascular protection, neurological effects, and body weight regulation.
| Structure | GLP-1(7-37) analogue: Aib8 substitution + C18 fatty diacid at Lys34 via linker |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | 4113.58 g/mol |
| CAS Number | 910463-68-2 |
| Purity | ≥95% (HPLC verified) |
| Format | Lyophilized powder |
| Quantity | 5mg per vial |
| Storage | -20°C, protect from light |
Key Research Applications
- GLP-1 receptor activation and cAMP/PKA signaling studies
- Pancreatic β-cell insulin secretion and proliferation models
- Appetite suppression and hypothalamic satiety signaling research
- Cardiovascular and cardiometabolic protection studies
- Neuroinflammation and neuroprotection models
- Fatty liver disease (NAFLD/NASH) preclinical research
- Obesity and type 2 diabetes animal models
Reconstitution: Add 1 mL of sterile bacteriostatic water. Gently swirl — do not shake. Store reconstituted peptide at 4°C and use within 28 days.
Research Use Only. This product is intended strictly for in vitro laboratory research. Not for human or veterinary use. Not evaluated by the FDA.
Researcher Resources
- semaglutide research overview — Mechanism & Published Research
- How to Reconstitute Peptides — Step-by-Step Researcher Guide
- Science & Quality — HPLC ≥99% Purity Standards
For laboratory research purposes only. Not for human consumption. These statements have not been evaluated by the U.S. Food and Drug Administration.





R. Calloway –
Semaglutide 5mg — clear solution post-reconstitution, no visible aggregation. Clean COA with HPLC trace provided. Would recommend for GLP-1 research setups.