Overview
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analogue of α-MSH and a metabolite of Melanotan II, acting as a melanocortin receptor agonist with high selectivity for MC3R and MC4R. Unlike Melanotan II, PT-141 does not have a free C-terminal amino group, resulting in distinct receptor binding characteristics. PT-141 is notable as the first peptide approved by the FDA for a sexual dysfunction indication, making it a well-characterized research compound with extensive published clinical and preclinical data.
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular Formula | C₅₀H₆₈N₁₄O₁₀ |
| Molecular Weight | 1025.17 g/mol |
| CAS Number | 189691-06-3 |
| Purity | ≥99% (HPLC verified) |
| Format | Lyophilized powder |
| Quantity | 10mg per vial |
| Storage | -20°C, protect from light |
Key Research Applications
- MC3R and MC4R selective agonism studies
- Central nervous system melanocortin pathway research
- Sexual function and arousal mechanism investigation
- Inflammation and immune modulation models
- Comparison with Melanotan II receptor binding profiles
- Clinical pharmacology reference studies (FDA-approved analogue)
Reconstitution: Add 1 mL of sterile bacteriostatic water. Gently swirl — do not shake. Store reconstituted peptide at 4°C and use within 14 days.
Research Use Only. This product is intended strictly for in vitro laboratory research. Not for human or veterinary use. Not evaluated by the FDA.
Researcher Resources
- pt 141 research overview — Mechanism & Published Research
- How to Reconstitute Peptides — Step-by-Step Researcher Guide
- Science & Quality — HPLC ≥99% Purity Standards
For laboratory research purposes only. Not for human consumption. These statements have not been evaluated by the U.S. Food and Drug Administration.
COA Available on Request
Lot-Specific Testing
Dr. K. Whitfield –
PT-141 compound was analytically verified before use. Consistent batch quality. Packaging maintained temperature throughout shipping.