Research use only. The compounds below are sold strictly as reference materials for in-vitro and laboratory research. Nothing here is medical advice, a dosing protocol, or an anti-aging claim — it summarises how the published literature characterises each molecule’s research mechanism. Every batch we list is published with its independent Janoshik HPLC certificate.
The short version
“Longevity research peptides” is a loose label for compounds studied in the biology of aging — but they do not share one mechanism. They cluster into two mechanistic groups, and choosing between them starts with knowing which group a compound belongs to:
- Telomere / pineal pathway — epithalon and pinealon, short peptides from the Khavinson research lineage.
- Mitochondrial / metabolic pathway — MOTS-c and NAD+, which act on cellular energy and redox biology.
Epithalon — the telomere/pineal reference
Epithalon (epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a peptide extract of the pineal gland. The published research — much of it from the Khavinson group — investigates two recurring themes: telomerase activity (effects on telomere maintenance in cell models) and pineal/circadian regulation (interaction with melatonin rhythms). It is the most-studied compound in this cluster and the usual starting point. Our epithalon research overview goes deeper into the literature.
Pinealon — the neuro/pineal short peptide
Pinealon (Glu-Asp-Arg) is another short “cytogen” peptide from the same research tradition. The literature focuses on neuroprotection models and pineal/brain research — distinct from epithalon’s telomere emphasis even though the two come from a shared lineage. It is studied where the question is cellular protection under stress rather than telomere length.
MOTS-c — the mitochondrial-derived peptide
MOTS-c is a mitochondrial-derived peptide: its sequence is encoded within the 12S rRNA region of mitochondrial DNA itself. Research characterises it as a metabolic regulator — studied in the context of insulin sensitivity, glucose metabolism, and as an “exercise-mimetic” signal in animal models. It is the compound of interest where the research question is mitochondrial-to-nuclear metabolic signalling.
NAD+ — the redox coenzyme
NAD+ (nicotinamide adenine dinucleotide) is not a peptide but a coenzyme central to cellular energy metabolism. It is grouped here because it anchors much of the mechanistic aging literature: it is the substrate for sirtuins (a family of enzymes tied to metabolic regulation) and for PARP DNA-repair enzymes, and cellular NAD+ availability is a recurring variable in aging-biology studies. It is the metabolic-cofactor reference point for the whole cluster.
Side-by-side
| Compound | Type | Pathway studied | Literature note |
|---|---|---|---|
| Epithalon | tetrapeptide | telomere / pineal | telomerase + melatonin-rhythm research |
| Pinealon | tripeptide | neuro / pineal | neuroprotection models |
| MOTS-c | mitochondrial peptide | mitochondrial / metabolic | insulin sensitivity, exercise-mimetic studies |
| NAD+ | coenzyme (dinucleotide) | redox / sirtuin / PARP | energy metabolism & DNA-repair substrate |
This summarises the research mechanism node each compound is associated with — not efficacy, outcomes, or any anti-aging benefit.
How researchers choose
- Telomere/telomerase question? Epithalon is the reference.
- Cellular neuroprotection under stress? Pinealon.
- Mitochondrial metabolic signalling / insulin sensitivity? MOTS-c.
- Redox cofactor availability, sirtuin or PARP biology? NAD+.
For a protocol spanning more than one node, the longevity stack groups the cluster together.
What the literature does NOT establish
None of these has established human anti-aging efficacy, a validated human dosing protocol, or long-term human safety data. A large share of the epithalon and pinealon work is from a single research lineage, and the MOTS-c/NAD+ aging literature is mostly preclinical. “Longevity” here describes the research field these compounds appear in, not a demonstrated effect. Treat all of them strictly as laboratory research compounds.
Handling and reconstitution
These ship as lyophilised powder and must be reconstituted before laboratory work; reconstitution volume sets concentration per unit, so calculate it with our reconstitution guide rather than estimating.
Verifying what you receive
For every batch we list, the independent Janoshik HPLC certificate that accompanies it is published — see the lab results archive; every task ID resolves on Janoshik’s own domain.
Frequently asked questions
What do these longevity research peptides have in common?
They appear in the biology-of-aging literature, but through different mechanisms: epithalon and pinealon in telomere/pineal research, MOTS-c and NAD+ in mitochondrial and redox metabolism. They are grouped by research field, not by a shared mechanism.
Is NAD+ a peptide?
No — NAD+ is a coenzyme (a dinucleotide), not a peptide. It is included here because it is central to the metabolic and DNA-repair pathways studied alongside these peptides.
What is epithalon studied for?
Primarily telomerase/telomere-maintenance effects in cell models and pineal/circadian (melatonin-rhythm) regulation. See the epithalon research overview linked above.
How is MOTS-c different from the others?
MOTS-c is a mitochondrial-derived peptide encoded in mitochondrial DNA; its research focus is metabolic signalling and insulin sensitivity, distinct from the telomere/pineal focus of epithalon and pinealon.
How do I verify the purity of the batch I receive?
Each batch we list is published with the independent Janoshik HPLC certificate that accompanies it, with a public verify link on Janoshik’s own domain.
Are these for human use?
No. They are sold strictly as research-use-only reference materials and are not intended for human or veterinary use.
Summary
Sort the longevity cluster by mechanism: telomere/pineal (epithalon, pinealon) versus mitochondrial/metabolic (MOTS-c, NAD+). Match the compound to the pathway your research isolates, reconstitute it correctly, and confirm the batch against its published Janoshik certificate before you begin.